Characterization of the Effects of an rpoC Mutation That Confers Resistance to the Fst Peptide Toxin-Antitoxin System Toxin
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چکیده
منابع مشابه
Bacterial Toxin-antitoxin Systems Translation Inhibitors Everywhere the Toxin-antitoxin System Framework the Selfish Nature of Toxin-antitoxin Systems
*Correspondence to: Laurence Van Melderen; Email: [email protected] Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which theymove via horizontal gene transfer. They are generally composed of two genes organized in an operon, encoding ...
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Introduction: Acinetobacter baumannii is one of the most important nosocomial and community-acquired pathogens that is resistant to many antibiotics. Toxin-antitoxin systems are regulatory systems that maintain bacteria and serve as new targets for Antimicrobial therapies are considered. The prevalence and transcription of these systems in clinical isolates is still unknown. The aim of this stu...
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Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins. SpoIISA is a membrane-bound protein, while SpoIISB and SpoIISC are small cytosolic antitoxins, which are able to bind SpoIISA and neutralize it...
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The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In contrast to other TA systems, [C117S]YmoB transiently interacts with Hha (rather than forming a stable complex) and enhances the spontaneous oxidati...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2013
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01597-12